For too long, people with profound autism have been left out of the research meant to help them. ARIA (Aligning Research to Impact Autism) is changing that, and Profound Autism Alliance is thrilled to promote these efforts. ARIA's IMPACT Network brings research sites around the world together to get new treatments ready for clinical trials and into the hands of families sooner. Our loved ones are at the center of this work.
The ARIA IMPACT-Ready Study follows children and young adults over time to learn how profound autism develops and changes. What researchers learn will help shape future clinical trials.
PAA does not fund ARIA or the IMPACT Network.
Our part is to:
Study design, site locations, eligibility details, and the full IMPACT-Ready Study FAQ are on the ARIA website.
Researchers can't learn about profound autism without people with profound autism.
A rising tide lifts all boats. Every family who participates, in any cohort, is contributing to something larger than any single condition. By studying participants in depth, researchers are uncovering shared biological pathways and perfecting measurement tools that can be applied across the entire autism spectrum. A discovery for one condition creates a wave of progress that accelerates answers, clinical readiness, and targeted support for everyone.
Participation also helps researchers understand how autism develops over time. This knowledge is essential for identifying the outcome measures and endpoints that will inform clinical trials of new therapies and supports.
Selected sites are implementing the ARIA IMPACT-Ready Study, is a 5-year, non-interventional natural history and clinical endpoint study launched by Aligning Research to Impact Autism (ARIA) through its international IMPACT Network. It gathers longitudinal data to build trial-ready infrastructure for profound autism and rare genetic neurodevelopmental conditions.
